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tertiary intratumor lymphoid tissue in colo-rectal cancer三级intratumor在结肠直肠癌淋巴组织
Cancers 2012, 4, 1-10; doi:10.3390/cancers4010001
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Article
Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer
Francesca Bergomas 1, Fabio Grizzi 2, Andrea Doni 1, Samantha Pesce 1, Luigi Laghi 2,3,
Paola Allavena 1, Alberto Mantovani 1,4 and Federica Marchesi 1,*
1 Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56,
20089 Rozzano, Milan, Italy; E-Mails: francesca.bergomas@humanitasresearch.it (F.B.);
andrea.doni@humanitasresearch.it (A.D.); samantha.pesce@humanitasresearch.it (S.P.);
paola.allavena@humanitasresearch.it (P.A.); alberto.mantovani@humanitasresearch.it (A.M.)
2 Laboratory of Molecular Gastroenterology, IRCCS Humanitas Clinical Institute, Via Manzoni 56,
20089 Rozzano, Milan, Italy; E-Mails: fabio.grizzi@humanitasresearch.it (F.G.);
luigi.laghi@humanitas.it (L.L.)
3 Department of Gastroenterology, IRCCS Humanitas Clinical Institute, Via Manzoni 56,
20089 Rozzano, Milan, Italy
4 Department of Translational Medicine, University of Milan, Milan 20089, Italy
* Author to whom correspondence should be addressed;
E-Mail: federica.marchesi@humanitasresearch.it; Tel.: +39-028-224-5113; Fax: +39-028-224-5101.
Received: 11 October 2011; in revised form: 15 November 2011 / Accepted: 21 December 2011 /
Published: 28 December 2011
Abstract: Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or
infection in non lymphoid organs and is associated with chronic inflammation.
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