tertiary intratumor lymphoid tissue in colo-rectal cancer三级intratumor在结肠直肠癌淋巴组织.pdfVIP

tertiary intratumor lymphoid tissue in colo-rectal cancer三级intratumor在结肠直肠癌淋巴组织.pdf

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tertiary intratumor lymphoid tissue in colo-rectal cancer三级intratumor在结肠直肠癌淋巴组织

Cancers 2012, 4, 1-10; doi:10.3390/cancers4010001 OPEN ACCESS cancers ISSN 2072-6694 /journal/cancers Article Tertiary Intratumor Lymphoid Tissue in Colo-Rectal Cancer Francesca Bergomas 1, Fabio Grizzi 2, Andrea Doni 1, Samantha Pesce 1, Luigi Laghi 2,3, Paola Allavena 1, Alberto Mantovani 1,4 and Federica Marchesi 1,* 1 Department of Immunology and Inflammation, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089 Rozzano, Milan, Italy; E-Mails: francesca.bergomas@humanitasresearch.it (F.B.); andrea.doni@humanitasresearch.it (A.D.); samantha.pesce@humanitasresearch.it (S.P.); paola.allavena@humanitasresearch.it (P.A.); alberto.mantovani@humanitasresearch.it (A.M.) 2 Laboratory of Molecular Gastroenterology, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089 Rozzano, Milan, Italy; E-Mails: fabio.grizzi@humanitasresearch.it (F.G.); luigi.laghi@humanitas.it (L.L.) 3 Department of Gastroenterology, IRCCS Humanitas Clinical Institute, Via Manzoni 56, 20089 Rozzano, Milan, Italy 4 Department of Translational Medicine, University of Milan, Milan 20089, Italy * Author to whom correspondence should be addressed; E-Mail: federica.marchesi@humanitasresearch.it; Tel.: +39-028-224-5113; Fax: +39-028-224-5101. Received: 11 October 2011; in revised form: 15 November 2011 / Accepted: 21 December 2011 / Published: 28 December 2011 Abstract: Ectopic (or tertiary) lymphoid tissue develops at sites of inflammation or infection in non lymphoid organs and is associated with chronic inflammation.

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