原创力文档the action mechanism of the myc inhibitor termed omomyc may give clues on how to target myc for cancer therapymyc抑制剂的作用机理称为omomyc可能给线索如何目标myc癌症治疗.pdfVIP
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the action mechanism of the myc inhibitor termed omomyc may give clues on how to target myc for cancer therapymyc抑制剂的作用机理称为omomyc可能给线索如何目标myc癌症治疗
The Action Mechanism of the Myc Inhibitor Termed
Omomyc May Give Clues on How to Target Myc for
Cancer Therapy
1 1 1 1 2¤a
Mauro Savino , Daniela Annibali , Nicoletta Carucci , Emilia Favuzzi , Michael D. Cole , Gerard I.
3¤b 3,4 1
Evan , Laura Soucek , Sergio Nasi *
`
1 Consiglio Nazionale delle Ricerche - Istituto di Biologia e Patologia Molecolari (CNR – IBPM), Dipartimento di Biologia e Biotecnologie, Universita Sapienza, Roma, Italia,
2 Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America, 3 Department of Pathology, University of California San
Francisco (UCSF), San Francisco, California, United States of America, 4 Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
Abstract
Recent evidence points to Myc – a multifaceted bHLHZip transcription factor deregulated in the majority of human cancers
– as a priority target for therapy. How to target Myc is less clear, given its involvement in a variety of key functions in healthy
cells. Here we report on the action mechanism of the Myc interfering molecule termed Omomyc, which demonstrated
astounding therapeutic efficacy in transgenic mouse cancer models in vivo. Omomyc action is different from the one that
can be obtained by gene knockout or RNA interference, approaches designed to block all functions of a gene product. This
molecule – instead – appears to cause an edge-specific perturbation that destroys some protein interactions of the Myc
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