原创力文档the active ingredients of jiang-zhi-ning study of the nelumbo nucifera alkaloids and their main bioactive metabolites莲属椰子的jiang-zhi-ning研究活性成分生物碱及其主要生物活性代谢物.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the active ingredients of jiang-zhi-ning study of the nelumbo nucifera alkaloids and their main bioactive metabolites莲属椰子的jiang-zhi-ning研究活性成分生物碱及其主要生物活性代谢物
Molecules 2012, 17, 9855-9867; doi:10.3390/molecule
OPEN ACCESS
molecules
ISSN 1420-3049
/journal/molecules
Article
The Active Ingredients of Jiang-Zhi-Ning:
Study of the Nelumbo nucifera Alkaloids and
Their Main Bioactive Metabolites
Jianxin Chen †, Xueling Ma †, Kuo Gao, Yong Wang, Huihui Zhao, Hao Wu, Juan Wang,
Hua Xie, Yulin OuYang, Liangtao Luo, Shuzhen Guo, Jing Han, Bing Liu and Wei Wang *
Beijing University of Chinese Medicine, 11 Bei San Huan Dong Lu, ChaoYang District,
Beijing 100029, China
† These authors contributed equally to this work.
* Author to whom correspondence should be addressed; E-Mail: wangwei@;
Tel.: +86-10-6428-6508; Fax: +86-10-6428-6283.
Received: 15 June 2012; in revised form: 12 July 2012 / Accepted: 17 July 2012 /
Published: 16 August 2012
Abstract: The object of this study was to identify the major active ingredients of
the Chinese Traditional Medicine Jiang-Zhi-Ning (JZN) based on the high performance
liquid chromatography (HPLC) profiles of plasma samples obtained from beagle dogs at
different times after intragastric administration of JZN, crude JZN extracts, different
extracted fractions, different subfractions of the active fraction and different isolated
ingredients. 2-Hydroxy-1-methoxyaporphin (2H1M), an alkaloid from Nelumbo nucifera,
one of the herbs that make up JZN, was identified as the constituent showing the major
pharmacodynamic effect. The major metabolites of 2H1M were analyzed and identified as
N-demethyl-2-hydroxy-1-methoxyapor
您可能关注的文档
- tannin fingerprinting in vegetable tanned leather by solid state nmr spectroscopy and comparison with leathers tanned by other processes单宁植物鞣皮指纹的固态核磁共振光谱和由其他进程与皮革鞣.pdf
- tannins of constant structure in medicinal and food plants—hydrolyzable tannins and polyphenols related to tannins单宁结构常数在医药和食品plants-hydrolyzable单宁和多酚与单宁.pdf
- tailored watershed assessment and integrated management (twaim) a systems thinking approach定制的分水岭评估和综合管理(twaim)系统思考的方法.pdf
- tapered optical fiber sensor for label-free detection of biomolecules锥形光纤传感器label-free生物分子的检测.pdf
- tapasin gene polymorphism in systemic onset juvenile rheumatoid arthritis a family-based case–control studytapasin基因多态性在系统性幼年型类风湿性关节炎发作的家族式的病例对照研究.pdf
- tal effectors target the c-terminal domain of rna polymerase ii (ctd) by inhibiting the prolyl-isomerase activity of a ctd-associated cyclophilintal效应器目标c端域的rna聚合酶ii(ctd)通过抑制prolyl-isomerase还有ctd-associated的活动.pdf
- tannins, peptic ulcers and related mechanisms单宁、消化性溃疡及相关机制.pdf
- target dna structure plays a critical role in rag transposition目标dna结构中起关键作用破布换位.pdf
- taqman real-time pcr detects avipoxvirus dna in blood of hawaìi `amakihi (hemignathus virens)taqman实时pcr检测avipoxvirus dna在夏威夷血液amakihi(hemignathus对).pdf
- target drug delivery system as a new scarring modulation after glaucoma filtration surgery目标药物输送系统作为一种新的青光眼滤过手术后疤痕调制.pdf
- the action of the sex linked barring gene on spanish chickens with gold plumage性的作用除了西班牙与黄金羽毛鸡基因有关.pdf
- the activity of spontaneous action potentials in developing hair cells is regulated by ca2+-dependence of a transient k+ current发展中毛细胞的自发动作电位的活动是由ca2 +依赖的瞬态k +电流.pdf
- the active metabolite of leflunomide, a77 1726, interferes with dendritic cell function的活性代谢物leflunomide a77 1726年,干扰树突状细胞的功能.pdf
- the acute management of trauma hemorrhage a systematic review of randomized controlled trials急性创伤出血的管理随机对照试验的系统评价.pdf
- the acute toxicity and hematological characterization of the effects of tentacle-only extract from the jellyfish cyanea capillata的急性毒性和血液特性的影响tentacle-only从水母中提取cyanea capillata.pdf
- the actions of exogenous leucine on mtor signalling and amino acid transporters in human myotubes外生的行为亮氨酸mtor信号和氨基酸转运蛋白在人类肌管.pdf
- the acute environment, rather than t cell subset pre-commitment, regulates expression of the human t cell cytokine amphiregulin严重的环境,而不是t细胞子集预先承诺,调节人类t细胞表达细胞因子amphiregulin.pdf
- the acceptability of rat trap use over pesticides for rodent control in two poor urban communities in south africa老鼠的可接受性陷阱使用杀虫剂对啮齿动物控制在两个在南非城市贫困社区.pdf
- the adaptive evolution database (taed)自适应进化数据库(助教).pdf
- the adfcofilin family actin-remodeling proteinsadfcofilin家族actin-remodeling蛋白质.pdf
文档评论（0）