原创力文档the active metabolite of leflunomide, a77 1726, increases the production of il-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes的活性代谢物leflunomide a77 1726年,增加了生产人类滑膜成纤维细胞中il - 1受体拮抗剂和关节软骨细胞.pdfVIP
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the active metabolite of leflunomide, a77 1726, increases the production of il-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes的活性代谢物leflunomide a77 1726年,增加了生产人类滑膜成纤维细胞中il - 1受体拮抗剂和关节软骨细胞
Available online /content/6/3/R181
Research article Open Access
The active metabolite of leflunomide, A77 1726, increases the
production of IL-1 receptor antagonist in human synovial
fibroblasts and articular chondrocytes
1 2 1 1 1
Gaby Palmer , Danielle Burger , Françoise Mezin , David Magne , Cem Gabay , Jean-Michel
Dayer2 and Pierre-André Guerne1
1Division of Rheumatology, University Hospital, and Department of Pathology, University of Geneva School of Medicine, Geneva, Switzerland
2Division of Immunology and Allergy, Department of Internal Medicine, University Hospital, Geneva, Switzerland
Corresponding author: Pierre-André Guerne (e-mail: Pierre-Andre.Guerne@medecine.unige.ch)
Received: 12 Sep 2003 Revisions requested: 10 Oct 2003 Revisions received: 27 Jan 2004 Accepted: 4 Feb 2004 Published: 19 Feb 2004
Arthritis Res Ther 2004, 6:R181-R189 (DOI 10.1186/ar1157)
© 2004 Palmer et al., licensee BioMed Central Ltd. This is an Open Access article: verbatim copying and redistribution of this article are permitted
in all media for any purpose, provided this notice is preserved along with the articles original URL.
Abstract
Leflunomide is an immunomodulatory agent used for the pyrimidine synthesis and cyclo-oxygenase (COX)-2 activity.
treatment of rheumatoid arthritis. In this study, we investigated Addition of exogenous uridine did not significantly modify the
the effect of A77 1726 – the active metabolite of leflunomide – effect of A77 1726 on IL-1Ra production, suggesting that it
on the production of IL-1 receptor antagonist (IL
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