the anti-tumor effect of a3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cellsa3腺苷酸受体的抗肿瘤效应会使脉冲电磁场在神经肿瘤细胞培养.pdfVIP

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the anti-tumor effect of a3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cellsa3腺苷酸受体的抗肿瘤效应会使脉冲电磁场在神经肿瘤细胞培养.pdf

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the anti-tumor effect of a3 adenosine receptors is potentiated by pulsed electromagnetic fields in cultured neural cancer cellsa3腺苷酸受体的抗肿瘤效应会使脉冲电磁场在神经肿瘤细胞培养

The Anti-Tumor Effect of A3 Adenosine Receptors Is Potentiated by Pulsed Electromagnetic Fields in Cultured Neural Cancer Cells 1 1 1 1 1 2 Fabrizio Vincenzi , Martina Targa , Carmen Corciulo , Stefania Gessi , Stefania Merighi , Stefania Setti , 2 1 1 Ruggero Cadossi , Pier Andrea Borea , Katia Varani * 1 Department of Clinical and Experimental Medicine, Pharmacology Unit, University of Ferrara, Ferrara, Italy, 2 Igea Biophysics Laboratory, Carpi, Italy Abstract A3 adenosine receptors (ARs) play a pivotal role in the development of cancer and their activation is involved in the inhibition of tumor growth. The effects of pulsed electromagnetic fields (PEMFs) on cancer have been controversially discussed and the detailed mechanisms are not yet fully understood. In the past we have demonstrated that PEMFs increased A and A AR density and functionality in human neutrophils, human and bovine synoviocytes, and bovine 2A 3 chondrocytes. In the same cells, PEMF exposure increased the anti-inflammatory effect mediated by A and/or A ARs. The 2A 3 primary aim of the present study was to evaluate if PEMF exposure potentiated the anti-tumor effect of A3ARs in PC12 rat adrenal pheochromocytoma and U87MG human glioblastoma cell lines in comparison with rat cortical neurons. Saturation binding assays and mRNA analysis revealed that PEMF exposure up-regulated A and A ARs that are well