原创力文档targeting receptor tyrosine kinases for chemoprevention by green tea catechin, egcg化学预防的目标受体酪氨酸激酶绿茶儿茶素、儿茶素.pdfVIP
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targeting receptor tyrosine kinases for chemoprevention by green tea catechin, egcg化学预防的目标受体酪氨酸激酶绿茶儿茶素、儿茶素
Int. J. Mol. Sci. 2008, 9, 1034-1049; DOI: 10.3390/ijms9061034
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/ijms
Review
Targeting Receptor Tyrosine Kinases for Chemoprevention by
Green Tea Catechin, EGCG
Masahito Shimizu *, Yohei Shirakami and Hisataka Moriwaki
Department of Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan
* Author to whom correspondence should be addressed; E-mail: shimim-gif@umin.ac.jp; Tel.: +81-(58)
230-6311; Fax: +81-(58) 230-6310;
Received: 12 May 2008; in revised form: 4 June 2008 / Accepted: 4 June 2008 / Published: 20 June 2008
Abstract: Tea is one of the most popular beverages consumed worldwide. Epidemiologic
studies show an inverse relationship between consumption of tea, especially green tea, and
development of cancers. Numerous in vivo and in vitro studies indicate strong
chemopreventive effects for green tea and its constituents against cancers of various
organs. (–)-Epigallocatechin-3-gallate (EGCG), the major catechin in green tea, appears to
be the most biologically active constituent in tea with respect to inhibiting cell
proliferation and inducing apoptosis in cancer cells. Recent studies indicate that the
receptor tyrosine kinases (RTKs) are one of the critical targets of EGCG to inhibit cancer
cell growth. EGCG inhibits the activ
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