原创力文档the burden and characteristics of enteric fever at a healthcare facility in a densely populated area of kathmandu伤寒肠热病的负担和特点在医疗保健设施在加德满都的人口稠密区.pdfVIP
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the burden and characteristics of enteric fever at a healthcare facility in a densely populated area of kathmandu伤寒肠热病的负担和特点在医疗保健设施在加德满都的人口稠密区
The Burden and Characteristics of Enteric Fever at a
Healthcare Facility in a Densely Populated Area of
Kathmandu
1 1 2 2,3 1 1
Abhilasha Karkey , Amit Arjyal , Katherine L. Anders , Maciej F. Boni , Sabina Dongol , Samir Koirala ,
2 2 4 5 2
Phan Vu Tra My , Tran Vu Thieu Nga , Archie C. A. Clements , Kathryn E. Holt , Pham Thanh Duy ,
2 2 6 2 2
Jeremy N. Day , James I. Campbell , Gordon Dougan , Christiane Dolecek , Jeremy Farrar , Buddha
1 2
Basnyat , Stephen Baker *
1 Oxford University Clinical Research Unit, Patan Academy of Health Sciences, Lagankhel, Kathmandu, Nepal, 2 Oxford University Clinical Research Unit, Wellcome Trust
Major Overseas Programme, The Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, 3 The MRC Centre for Genomics and Global Health, Oxford, United Kingdom,
4 School of Population Health, University of Queensland, Brisbane, Australia, 5 Department of Microbiology and Immunology, The University of Melbourne, Melbourne,
Australia, 6 Wellcome Trust Sanger Institute, Cambridge, United Kingdom
Abstract
Enteric fever, caused by Salmonella enterica serovars Typhi and Paratyphi A (S. Typhi and S. Paratyphi A) remains a major
public health problem in many settings. The disease is limited to locations with poor sanitation which facilitates the
transmission of the infecting organisms. Efficacious and inexpensive vaccines are available for S. Typhi, yet are not
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