the chemopreventive effects of protandim modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesisp53的chemopreventive protandim调制的影响线粒体易位和细胞凋亡在皮肤致癌作用.pdfVIP

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the chemopreventive effects of protandim modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesisp53的chemopreventive protandim调制的影响线粒体易位和细胞凋亡在皮肤致癌作用.pdf

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the chemopreventive effects of protandim modulation of p53 mitochondrial translocation and apoptosis during skin carcinogenesisp53的chemopreventive protandim调制的影响线粒体易位和细胞凋亡在皮肤致癌作用

The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis during Skin Carcinogenesis 1 2 6 1 3 4 5 Delira Robbins , Xin Gu , Runhua Shi , Jianfeng Liu , Fei Wang , Jacqulyne Ponville , Joe M. McCord , Yunfeng Zhao1* 1 Department of Pharmacology, Toxicology and Neuroscience, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, 2 Department of Pathology, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America, 3 College of Life Science, Jilin University, Changchun, Jilin Province, China, 4 Department of Chemistry, Nicholls State University, Thibodaux, Louisiana, United States of America, 5 Department of Medicine, University of Colorado at Denver and Health Sciences Center, Aurora, Colorado, United States of America, 6 Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, Shreveport, Louisiana, United States of America Abstract Protandim, a well defined dietary combination of 5 well-established medicinal plants, is known to induce endogenous antioxidant enzymes, such as manganese superoxide dismutase (MnSOD). Our previous studies have shown through the induction of various antioxidant enzymes, products of oxidative damage can be decreased. In addition, we have shown that tumor multiplicity and incidence can be decreased through the dietary administration of Protandim in the two-stage skin carcinogenesis mouse model. It has been demonstrated that cell proliferation is accommodated by cell death during DMBA/ TPA treatment in the two-stage skin carcinogenesis model. Therefore, we investigated the effects of the Protandim diet on apoptosis; and propos