原创力文档the 1000 genomes project new opportunities for research and social challenges1000人基因组计划研究新的机遇和社会挑战.pdfVIP
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the 1000 genomes project new opportunities for research and social challenges1000人基因组计划研究新的机遇和社会挑战
Via et al. Genome Medicine 2010, 2:3
/content/2/1/3
COMMENTARY
The 1000 Genomes Project: new opportunities for
research and social challenges
Marc Via*, Christopher Gignoux and Esteban González Burchard
community is turning its attention to the 1000 Genomes
Abstract
Project [1], an international collaboration between
The 1000 Genomes Project, an international China, Germany, the UK, and the USA. e initial goal
collaboration, is sequencing the whole genome was to discover most of the genetic variation that occurs
of approximately 2,000 individuals from dierent at a population frequency greater than 1% by deep
worldwide populations. The central goal of this project sequencing at least 1,000 individuals from different
is to describe most of the genetic variation that occurs worldwide populations using next-generation platforms
at a population frequency greater than 1%. The results and technologies. e genomes of approximately 2,000
of this project will allow scientists to identify genetic individuals, from at least 20 different populations
variation at an unprecedented degree of resolution representing Africa, Europe, East Asia, and the Americas,
and will also help improve the imputation methods are being collected and sequenced. e populations
for determining unobserved genetic variants that included will each have approximately 60 to 100 samples
are not represented on current genotyping arrays. By sequenced. For some
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