the aaa+ superfamily of functionally diverse proteins功能多样的蛋白质的aaa +总科.pdfVIP

Review TThhee AAAAAA++ ssuuppeerrffaammiillyy ooff ffuunnccttiioonnaallllyy ddiivveerrssee pprrootteeiinnss ¤ ¤ Jamie Snider , Guillaume Thibault and Walid A Houry Address: Department of Biochemistry, University of Toronto, Medical Sciences Building, 1 King’s College Circle, Toronto, Ontario M5S 1A8, Canada. ¤These authors contributed equally to this work Correspondence: Walid A Houry. Email: walid.houry@utoronto.ca Published: 30 April 2008 Genome BBiioollooggyy 2008, 99::216 (doi:10.1186/gb-2008-9-4-216) The electronic version of this article is the complete one and can be found online at /2008/9/4/216 © 2008 BioMed Central Ltd SSuummmmaarryy The AAA+ superfamily is a large and functionally diverse superfamily of NTPases that are characterized by a conserved nucleotide-binding and catalytic module, the AAA+ module. Members are involved in an astonishing range of different cellular processes, attaining this functional diversity through additions of structural motifs and modifications to the core AAA+ module. The ‘ATPases associated with diverse cellular activities’ expanded and adapted to allow the processing of a wide (AAA+ proteins) form a large and diverse superfamily found variety of targets. Furthermore, the emergence of partner in all organisms. These proteins typically assemble into proteins and cofactors has increased the functional diversity hexameric ring complexes that are involved in the energy- of AAA+ proteins [1,5]. dependent remodeling of macromolecules [1]. Members o