原创力文档the clathrin assembly protein picalm is required for erythroid maturation and transferrin internalization in mice所需的网格蛋白组装蛋白质picalm红细胞成熟和转铁蛋白在老鼠身上内化.pdfVIP
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the clathrin assembly protein picalm is required for erythroid maturation and transferrin internalization in mice所需的网格蛋白组装蛋白质picalm红细胞成熟和转铁蛋白在老鼠身上内化
The Clathrin Assembly Protein PICALM Is Required for
Erythroid Maturation and Transferrin Internalization in
Mice
1 2 3 4 4 2
Mai Suzuki , Hirokazu Tanaka , Akira Tanimura , Kenji Tanabe , Natsuko Oe , Shinya Rai , Syunsuke
5 6 4 7 2 3
Kon , Manabu Fukumoto , Kohji Takei , Takaya Abe , Itaru Matsumura , Yuzuru Kanakura , Toshio
Watanabe1*
1 Department of Biological Science, Graduate School of Humanities and Sciences, Nara Women’s University, Nara, Japan, 2 Division of Hematology, Department of Internal
Medicine, Kinki University, Osaka, Japan, 3 Department of Hematology and Oncology, Osaka University Graduate School of Medicine, Osaka, Japan, 4 Department of
Neuroscience, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama, Japan, 5 Department of Molecular Immunology,
Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 6 Department of Pathology, Institute of Development, Aging and Cancer, Tohoku
University, Sendai, Japan, 7 Laboratory for Animal Resources and Genetic Engineering, RIKEN Center for Developmental Biology, Kobe, Japan
Abstract
Phosphatidylinositol binding clathrin assembly protein (PICALM), also known as clathrin assembly lymphoid myeloid
leukemia protein (CALM), was originally isolated as part of the fusion gene CALM/AF10, which results from the chromosomal
translocation t(10;11)(p13;q14). CALM is sufficient to drive clathrin assembly in vitro on lipid monolayers and regulates
clathrin-coated budding and the size and shape of the vesicles at the plasma membrane. Ho
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