原创力文档the crosstalk of ptgs2 and egf signaling pathways in colorectal cancerptgs2相声和表皮生长因子信号通路在结肠直肠癌.pdfVIP
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the crosstalk of ptgs2 and egf signaling pathways in colorectal cancerptgs2相声和表皮生长因子信号通路在结肠直肠癌
Cancers 2011, 3, 3894-3908; doi:10.3390/cancers3043894
OPEN ACCESS
cancers
ISSN 2072-6694
/journal/cancers
Review
The Crosstalk of PTGS2 and EGF Signaling Pathways in
Colorectal Cancer
Dingzhi Wang 1, Dianren Xia 1 and Raymond N. DuBois 1,2,*
1 Departments of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston,
TX 77030, USA; E-Mails: dwang11@ (D.W.); dxia@ (D.X.)
2 Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center,
1515 Holcombe Blvd., Houston, TX 77030, USA
* Author to whom correspondence should be addressed; E-Mail: rdubois@;
Tel.: +1-713-745-4495; Fax: +1-713-792-6375.
Received: 13 September 2011; in revised form: 7 October 2011 / Accepted: 9 October 2011 /
Published: 14 October 2011
Abstract: Colorectal cancer (CRC) is now the second-leading cause of cancer deaths in the
USA. Colorectal cancer progression and metastasis depends on the orchestration of the
aberrant signaling pathways that control tumor cell proliferation, survival and
migration/invasion. Epidemiological, clinical, and animal studies have demonstrated that
prostaglandin-endoperoxide synthase 2 (PTGS2) and epithelial growth factor (EGF)
signaling pathways play key roles in promoting colorectal cancer growth and metastasis. In
this review, we highlight major advances in our understanding of the roles of PTGS2 and
EGF signaling in colorectal cancer.
Keywords: PTGS2; COX-2; EGFR; colorectal cancer
1. Introduction
Colorect
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