原创力文档the development of 3-d, in vitro, endothelial culture models for the study of coronary artery disease三维的发展,体外内皮文化模型研究冠状动脉疾病.pdfVIP
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the development of 3-d, in vitro, endothelial culture models for the study of coronary artery disease三维的发展,体外内皮文化模型研究冠状动脉疾病
BioMedical Engineering OnLine BioMed Central
Research Open Access
The development of 3-D, in vitro, endothelial culture models
for the study of coronary artery disease
1 1 2 1
Monica A Farcas , Leonie Rouleau , Richard Fraser and Richard L Leask*
Address: 1Department of Chemical Engineering, McGill University, Montreal, Canada and 2Department of Pathology, McGill University, Montreal,
Canada
Email: Monica A Farcas - monica.farcas@utoronto.ca; Leonie Rouleau - leonie.rouleau@; Richard Fraser - richard.fraser@mcgill.ca;
Richard L Leask* - richard.leask@mcgill.ca
* Corresponding author
Published: 28 October 2009 Received: 30 June 2009
Accepted: 28 October 2009
BioMedical Engineering OnLine 2009, 8:30 doi:10.1186/1475-925X-8-30
This article is available from: /content/8/1/30
© 2009 Farcas et al; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The response of the vascular endothelium to wall shear stress plays a central role in the
development and progression of atherosclerosis. Current studies have investigated endothelial
response using idealized in vitro flow chambers. Such cell culture models are unable to accura
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