原创力文档the drug release profile from calcium-induced alginate gel beads coated with an alginate hydrolysate药物释放概要文件从calcium-induced藻酸盐凝胶珠的海藻酸水解物.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the drug release profile from calcium-induced alginate gel beads coated with an alginate hydrolysate药物释放概要文件从calcium-induced藻酸盐凝胶珠的海藻酸水解物
Molecules 2007, 12, 2559-2566
molecules
ISSN 1420-3049
© 2007 by MDPI
/molecules
Full Paper
The Drug Release Profile from Calcium-induced Alginate Gel
Beads Coated with an Alginate Hydrolysate
1.* 1 2 1 1
Yoshifumi Murata , Daisaku Jinno , Dongchun Liu , Takshi Isobe , Kyouko Kofuji and
1
Susumu Kawashima
1 Faculty of Pharmaceutical Science, Hokuriku University, Ho-3, Kanagawa-machi, Kanazawa
920-1181, Japan
2 Department of Pharmacognosy, Shenyang Pharmaceutical University, Wen Hua Road 103, mailbox
48, Shenhe, Shenyang, 110016, PRC
* Author to whom correspondence should be addressed; E-mail: y-murata@hokuriku-u.ac.jp; Phone:
+81-076-229-6184; Fax: +81-076-229-2781
Received: 17 November 2007; in revised form: 27 November / Accepted: 27 November 2007 /
Published: 29 November 2007
Abstract: Calcium-induced alginate gel bead (Alg-Ca) coated with an alginate hydrolysate
(Alg), e.g. the guluronic acid block (GB) was prepared and the model drug, hydrocortisone
release profiles were investigated under simulated gastrointestinal conditions. Their
molecular weights were one sixth or one tenth that of Alg and the diffraction patterns of the
hydrolysates resembled that of Alg. The drug release rate from Alg-Ca coated with GB
apparently lowered than that of Alg-Ca (coating-free) in the gastric juice (pH1.2). And the
coating did not resist the disintegration of Alg-Ca in the in
您可能关注的文档
- the clinical and molecular spectrum of galactosemia in patients from the cape town region of south africa半乳糖血症的临床和分子光谱来自南非的开普敦地区的患者.pdf
- the city of man, european émigrés, and the genesis of postwar conservative thought人的城,欧洲移民,战后的保守思想的起源.pdf
- the circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitiscircumventricular器官参与实验性自身免疫性脑脊髓炎的免疫发病机理.pdf
- the clinical course of acute otitis media in high-risk australian aboriginal children a longitudinal study急性中耳炎的临床病程在高危澳大利亚土著儿童纵向研究.pdf
- the classical pink-eyed dilution mutation affects angiogenic responsiveness古典pink-eyed稀释突变影响血管生成反应.pdf
- the clinical global impression scale and the influence of patient or staff perspective on outcome全球临床印象规模和病人或员工视角的影响的结果.pdf
- the clinical implications of adult-onset henoch-schonelin purpura成人henoch-schonelin紫癜的临床意义.pdf
- the clathrin assembly protein picalm is required for erythroid maturation and transferrin internalization in mice所需的网格蛋白组装蛋白质picalm红细胞成熟和转铁蛋白在老鼠身上内化.pdf
- the clinical significance of unknown sequence variants in brca genes未知的brca基因序列变异的临床意义.pdf
- the clinical relevance of autoantibodies in scleroderma自身抗体在硬皮病的临床意义.pdf
- the drosophila trpp cation channel, pkd2 and dmelced-12 act in genetically distinct pathways during apoptotic cell clearance果蝇trpp阳离子通道,pkd2和dmelced-12法案在遗传学上截然不同的途径凋亡细胞间隙.pdf
- the dual impact of hiv-1 infection and aging on na？ve cd4+ t-cells additive and distinct patterns of impairmenthiv - 1感染的双重影响和衰老na ve cd4 + t细胞添加剂和不同模式的障碍.pdf
- the dual orexinhypocretin receptor antagonist, almorexant, in the ventral tegmental area attenuates ethanol self-administrationalmorexant双重orexinhypocretin受体拮抗剂,在腹侧被盖区减弱乙醇自治.pdf
- the dose and dose-rate effects of paternal irradiation on transgenerational instability in mice a radiotherapy connection父亲的辐照的剂量和剂量率效应在小鼠放疗连接继代不稳定.pdf
- the driving forces of guest substitution in gas hydrates—a laser raman study on ch4-co2 exchange in the presence of impurities客人替换的驱动力气体保湿激光拉曼研究ch4-co2交易所存在的杂质.pdf
- the dundrum-1 structured professional judgment for triage to appropriate levels of therapeutic security retrospective-cohort validation study分流的dundrum-1结构化的职业判断适当的治疗水平安全验证回顾性队列研究.pdf
- the dual role of inflammation in colon carcinogenesis结肠炎症在致癌作用的双重角色.pdf
- the durability of public goods changes the dynamics and nature of social dilemmas公共产品的耐久性变化动态和社会困境的性质.pdf
- the duke university religion index (durel) a five-item measure for use in epidemological studies杜克大学宗教指数(durel)five-item措施用于epidemological研究.pdf
- the dutpase enzyme is essential in mycobacterium smegmatisdutpase酶在smegmatis分枝杆菌至关重要.pdf
文档评论（0）