原创力文档the circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitiscircumventricular器官参与实验性自身免疫性脑脊髓炎的免疫发病机理.pdfVIP
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the circumventricular organs participate in the immunopathogenesis of experimental autoimmune encephalomyelitiscircumventricular器官参与实验性自身免疫性脑脊髓炎的免疫发病机理
Cerebrospinal Fluid Research BioMed Central
Research Open Access
The circumventricular organs participate in the
immunopathogenesis of experimental autoimmune
encephalomyelitis
2 1,2,3
Martina Schulz and Britta Engelhardt*
1 2
Address: Theodor Kocher Institute, University of Bern, CH-3012 Bern, Switzerland, Kerckhoff Institute, Department of Vascular Biology, Bad
Nauheim, Germany and 3Max-Planck Institute for Molecular Biomedicine, Münster, Germany
Email: Martina Schulz - Martina_Schulz@t-online.de; Britta Engelhardt* - bengel@tki.unibe.ch
* Corresponding author
Published: 30 September 2005 Received: 15 July 2005
Accepted: 30 September 2005
Cerebrospinal Fluid Research 2005, 2:8 doi:10.1186/1743-8454-2-8
This article is available from: /content/2/1/8
© 2005 Schulz and Engelhardt; licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: During inflammatory conditions of the central nervous system (CNS), such as in
multiple sclerosis or in its animal model, experimental autoimmune encephalomyelitis (EAE),
immune cells migrate from the blood stream into the CNS parenchyma and into the cerebrospinal
fluid (CS
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