the effect of acute kidney injury on long-term health-related quality of life a prospective follow-up study急性肾损伤的影响长期健康相关生活质量的一个前瞻性随访研究.pdfVIP

Hofhuis et al. Critical Care 2013, 17:R17 /content/17/1/R17 RESEARCH Open Access The effect of acute kidney injury on long-term health-related quality of life: a prospective follow-up study 1* 2 2 1 1,3 José GM Hofhuis , Henk F van Stel , Augustinus JP Schrijvers , Johannes H Rommes and Peter E Spronk Abstract Introduction: Acute kidney injury (AKI) is a serious complication in critically ill patients admitted to the Intensive Care Unit (ICU). We hypothesized that ICU survivors with AKI would have a worse health-related quality of life (HRQOL) outcome than ICU survivors without AKI. Methods: We performed a long-term prospective observational study. Patients admitted for 48 hours in a medical-surgical ICU were included and divided in two groups: patients who fulfilled RIFLE criteria for AKI and patients without AKI. We used the Short-Form 36 to evaluate HRQOL before admission (by proxy within 48 hours after admission of the patient), at ICU discharge, hospital discharge, 3 and 6 months following ICU discharge (all by patients). Recovery in HRQOL from ICU-admission onwards was assessed using linear mixed modelling. Results: Between September 2000 and January 2007 all admissions were screened for study participation. We included a total of 749 patients. At six months after ICU discharge 73 patients with AKI and 325 patients without AKI could be evaluated. In survivors with and without AKI, the pre-admission HRQOL (by proxy) and at six months after ICU discharge was significantly lower compared with an age matched general population. Most SF-36 dimensions changed significantly over time from ICU discharge. Change over time of HRQOL between the different AKI Rifle cla