the effects of exercise on c-reactive protein, insulin, leptin and some cardiometabolic risk factors in egyptian children with or without metabolic syndrome运动对c反应蛋白的影响,胰岛素、瘦素和一些代谢疾病危险因素在埃及的孩子或没有代谢综合征.pdfVIP

Kamal and Ragy Diabetology Metabolic Syndrome 2012, 4:27 DIABETOLOGY /content/4/1/27 METABOLIC SYNDROME RESEARCH Open Access The effects of exercise on C-reactive protein, insulin, leptin and some cardiometabolic risk factors in Egyptian children with or without metabolic syndrome Nashwa Nabil Kamal1* and Merhan Mamdouh Ragy2 Abstract Background: The prevalence and magnitude of obesity in the children and the adolescents have increased dramatically in the developing countries over the last 20–30 years. The prevalence of metabolic syndrome (MS) in children is increasing. Aim: This study aimed to investigate the changes of C-reactive protein (CRP), leptin, insulin, and blood lipids before and after the exercise therapy in normal and obese children (with or without metabolic syndrome). Methods: The study covered 49 normal children (control), 32 obese children without metabolic syndrome and 12 obese children with metabolic syndrome. We examined the influence of exercise (3 times/week) for 12 weeks on the levels of serum CRP, leptin, insulin, homeostatic model assessment insulin resistance (HOMA-IR), triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) in all groups. Results: There were significant correlations between HOMA-IR and the individual components of the metabolic syndrome. After 12 weeks of exercise, both of the obese children groups, with and without metabolic syndrome, showed reduced body weight, body mass index (BMI), and CRP level, and increased HDL-C level. The percentage of metabolic syndrome decrease