the ikappab kinase family phosphorylates the parkinson’s disease kinase lrrk2 at ser935 and ser910 during toll-like receptor signalingikappab激酶家族帕金森病体内基因lrrk2激酶磷酸化在ser935和ser910 toll样受体信号.pdfVIP

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the ikappab kinase family phosphorylates the parkinson’s disease kinase lrrk2 at ser935 and ser910 during toll-like receptor signalingikappab激酶家族帕金森病体内基因lrrk2激酶磷酸化在ser935和ser910 toll样受体信号.pdf

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the ikappab kinase family phosphorylates the parkinson’s disease kinase lrrk2 at ser935 and ser910 during toll-like receptor signalingikappab激酶家族帕金森病体内基因lrrk2激酶磷酸化在ser935和ser910 toll样受体信号

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling 1 1 1 2 2 Nicolas Dzamko *, Francisco Inesta-Vaquera , Jiazhen Zhang , Chengsong Xie , Huaibin Cai , 1 3,4 3,4 3,4 1 5 Simon Arthur , Li Tan , Hwanguen Choi , Nathanael Gray , Philip Cohen , Patrick Pedrioli , 1 1 Kristopher Clark , Dario R. Alessi * 1 MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, Scotland, 2 Transgenic Section, Laboratory of Neurogenetics, National Institute of Aging, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, United States of America, 3 Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 4 Department of Biological Chemistry and Molecular Pharmacology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, United States of America, 5 Scottish Institute of Life Sciences, College of Life Sciences, University of Dundee, Dow Street, Dundee Scotland Abstract Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson’s disease. LRRK2 is highly expressed in immune cells and recent work points towards a link between LRRK2 and innate immunity. Here we demonstrate that stimulation of the Toll-Like Receptor (TLR) pathway by MyD88-dependent agonists in bone marrow-derived macrophages (BMDMs) or RAW264.7 macrophages induces mark