the impact of social disparity on prefrontal function in childhood社会差距的影响前额叶功能的童年.pdfVIP

The Impact of Social Disparity on Prefrontal Function in Childhood 1,2 3 4 5,6 7 Margaret A. Sheridan *, Khaled Sarsour , Douglas Jutte , Mark D’Esposito , W. Thomas Boyce 1 School of Public Health, Harvard University, Boston, Massachusetts, United States of America, 2 Children’s Hospital Boston, Boston, Massachusetts, United States of America, 3 Eli Lilly and Company, Indianapolis, Indiana, United States of America, 4 School of Public Health, University of California, Berkeley, California, United States of America, 5 Helen Wills Neuroscience Institute, Berkeley, California, United States of America, 6 Psychology Department, University of California, Berkeley, California, United States of America, 7 College for Interdisciplinary Studies and Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada Abstract The prefrontal cortex (PFC) develops from birth through late adolescence. This extended developmental trajectory provides many opportunities for experience to shape the structure and function of the PFC. To date, a few studies have reported links between parental socioeconomic status (SES) and prefrontal function in childhood, raising the possibility that aspects of environment associated with SES impact prefrontal function. Considering that behavioral measures of prefrontal function are associated with learning across multiple domains, this is an important area of investigation. In this study, we used fMRI to replicate previous findings, demonstrating an association between parental SES and PFC function during childhood. In addition, we present two hypothetical mechanisms by which SES could come to affect PFC function of this association: language environment