原创力文档ultrasound biomicroscopy for longitudinal studies of carotid plaque development in mice validation with histological endpoints超声波活组织镜检查颈动脉斑块发展的纵向研究老鼠与组织学验证端点.pdfVIP
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ultrasound biomicroscopy for longitudinal studies of carotid plaque development in mice validation with histological endpoints超声波活组织镜检查颈动脉斑块发展的纵向研究老鼠与组织学验证端点
Ultrasound Biomicroscopy for Longitudinal Studies of
Carotid Plaque Development in Mice: Validation with
Histological Endpoints
1 1 2 3 4¤
Erin Y. Harmon , Van Fronhofer , Rebecca S. Keller , Paul J. Feustel , M. Julia Brosnan , Jan H. von der
¨ 5 2 1,2
Thusen , Daniel J. Loegering , Michelle R. Lennartz *
1 Center for Cell Biology and Cancer Research, Albany Medical College, Albany, New York, United States of America, 2 Center for Cardiovascular Sciences, Albany Medical
College, Albany, New York, United States of America, 3 Center for Neuropharmacology and Neuroscience, Ordway Research Institute, Albany, New York, United States of
America, 4 Center for Metabolic Disease, Ordway Research Institute, Albany, New York, United States of America, 5 Department of Pathology, Academic Medical Center,
Amsterdam, The Netherlands
Abstract
Atherosclerosis is responsible for the death of thousands of Americans each year. The carotid constriction model of plaque
development has recently been presented as a model for unstable plaque formation in mice. In this study we 1) validate
ultrasound biomicroscopy (UBM) for the determination of carotid plaque size, percent stenosis, and plaque development in
live animals, 2) determine the sensitivity of UBM in detecting changes in blood flow induced by carotid constriction and 3)
test whether plaque formation can be predicted from blood flow parameters measured by UBM. Carotid plaques were
induced by surgical constriction in Apo E2/ 2 mice. Arteries were imaged bi-weekly by UBM, at which time PW-Doppler
measurements of proximal blood flow, as well as plaque length and pe
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