understanding the molecular circuitry of cell lineage specification in the early mouse embryo理解细胞谱系的分子电路规范在小鼠早期胚胎.pdfVIP

Genes 2011, 2, 420-448; doi:10.3390/genes2030420 OPEN ACCESS genes ISSN 2073-4425 /journal/genes Review Understanding the Molecular Circuitry of Cell Lineage Specification in the Early Mouse Embryo Anna Bergsmedh 1,†, Mary E. Donohoe 2,3,†,*, Rebecca-Ayme Hughes 2 and Anna-Katerina Hadjantonakis 4,* 1 Center for Reproductive Medicine and Infertility, Weill Cornell Medical College, New York, NY 10065, USA; E-Mail: anna.bergsmedh@ (A.B.) 2 Burke Medical Research Institute, White Plains, NY 10605, USA; E-Mail: reh2010@ 3 Departments of Neuroscience and Cell and Developmental Biology, Weill Cornell Medical College, New York, NY 10065, USA 4 Developmental Biology Program, Sloan-Kettering Institute, New York, NY 10065, USA * Author to whom correspondence should be addressed; E-Mails: hadj@ (A.-K.H.); med2008@ (M.E.D.) † These authors contributed equally to this work. Received: 2 June 2011; in revised form: 24 June 2011 / Accepted: 5 July 2011 / Published: 13 July 2011 Abstract: Pluripotent stem cells hold great promise for cell-based therapies in regenerative medicine. However, critical to understanding and exploiting mechanisms of cell lineage specification, epigenetic reprogramming, and the optimal environment for maintaining and differentiating pluripotent stem cells is a fundamental knowledge of how these events occur in normal embryogenesis. The early mouse embryo has provided an excellent model to interrogate events crucial in cell lineage commitment and plasticity, as well as for embryo-der