variant g57e of mannose binding lectin associated with protection against tuberculosis caused by mycobacterium africanum but not by m. tuberculosis变体g57e甘露糖结合凝集素与预防结核分枝杆菌引起的africanum但不是由结核分枝杆菌.pdfVIP

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variant g57e of mannose binding lectin associated with protection against tuberculosis caused by mycobacterium africanum but not by m. tuberculosis变体g57e甘露糖结合凝集素与预防结核分枝杆菌引起的africanum但不是由结核分枝杆菌.pdf

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variant g57e of mannose binding lectin associated with protection against tuberculosis caused by mycobacterium africanum but not by m. tuberculosis变体g57e甘露糖结合凝集素与预防结核分枝杆菌引起的africanum但不是由结核分枝杆菌

Variant G57E of Mannose Binding Lectin Associated with Protection against Tuberculosis Caused by Mycobacterium africanum but not by M. tuberculosis 1,2. 3. 4 3 1,2 Thorsten Thye , Stefan Niemann , Kerstin Walter , Susanne Homolka , Christopher D. Intemann , 5 6 5 5 6,7 Margaret Amanua Chinbuah , Anthony Enimil , John Gyapong , Ivy Osei , Ellis Owusu-Dabo , Sabine ¨ 3 1 4,8 1 Rusch-Gerdes , Rolf D. Horstmann , Stefan Ehlers , Christian G. Meyer * 1 Department of Molecular Medicine, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany, 2 Institute of Medical Biometry and Statistics, University Hospital ¨ ¨ Schleswig-Holstein, Campus Lubeck, Lubeck, Germany, 3 National Reference Center for Mycobacteria, Research Center Borstel, Borstel, Germany, 4 Microbial Inflammation Research, Research Center Borstel, Borstel, Germany, 5 Health Research Unit, Ghana Health Service, Accra, Ghana, 6 Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana, 7 Deptartment of Community Health, School of Medical Sciences, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, 8 Cluster of Excellence Inflammation at Interfaces, Institute for Experimental Medicine, Kiel, Germany Abstract Structural variants of the Mannose Binding Lectin (MBL) cause quantitative and qualitative functional deficiencies, which are