原创力文档variation in effects of non-hodgkin lymphoma risk factors according to the human leukocyte antigen (hla)-drb10101 allele and ancestral haplotype 8.1非霍奇金淋巴瘤的风险因素变化的影响根据人类白细胞抗原(hla)-drb10101等位基因和祖先的单体型8.1.pdfVIP
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variation in effects of non-hodgkin lymphoma risk factors according to the human leukocyte antigen (hla)-drb10101 allele and ancestral haplotype 8.1非霍奇金淋巴瘤的风险因素变化的影响根据人类白细胞抗原(hla)-drb10101等位基因和祖先的单体型8.1
Variation in Effects of Non-Hodgkin Lymphoma Risk
Factors According to the Human Leukocyte Antigen
(HLA)-DRB1*01:01 Allele and Ancestral Haplotype 8.1
1 1 2 3 4
Sophia S. Wang *, Yani Lu , Nathaniel Rothman , Amr M. Abdou , James R. Cerhan , Anneclaire De
5 5 6 7 2 1
Roos , Scott Davis , Richard K. Severson , Wendy Cozen , Stephen J. Chanock , Leslie Bernstein ,
Lindsay M. Morton2, Patricia Hartge2
1 Division of Cancer Etiology, Department of Population Sciences, Beckman Research Institute and City of Hope, Duarte, California, United States of America, 2 Division of
Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health (NIH), United States Department of Human Health Services (DHHS), Rockville,
Maryland, United States of America, 3 Department of Microbiology and Immunology, National Research Center, Cairo, Egypt, 4 Division of Epidemiology, College of
Medicine, Mayo Clinic, Rochester, Minnesota, United States of America, 5 Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, United
States of America, 6 Department of Family Medicine and Public Health Sciences, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, United States of
America, 7 Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California, United States of America
Abstract
Genetic variations in human leukocyte antigens (HLA) are critical in host responses to infections, transplantation, and
immunological diseases. We previously identified associations with non-Hodgkin lymphoma (NHL) and the HLA-DRB1*01:01
allele and extended ancestral hapl
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