原创力文档variation in gys1 interacts with exercise and gender to predict cardiovascular mortalitygys1的变化与运动和性别预测心血管疾病的死亡率.pdfVIP
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variation in gys1 interacts with exercise and gender to predict cardiovascular mortalitygys1的变化与运动和性别预测心血管疾病的死亡率
Variation in GYS1 Interacts with Exercise and Gender to
Predict Cardiovascular Mortality
1 1,2 1 ¨ 1 1 1 3 4
Jenny Fredriksson , Dragi Anevski , Peter Almgren , Marketa Sjogren , Valeriya Lyssenko , Joyce Carlson , Bo Isomaa , Marja-Riitta Taskinen ,
1,4,5 1
Leif Groop , Marju Orho-Melander *, for the Botnia Study Group
¨ ¨
1 Department of Clinical Sciences in Malmo, Clinical Research Centre, Lund University, Malmo, Sweden, 2 Department of Mathematical Sciences,
¨ ¨ ¨
Chalmers University of Technology, Goteborg, Sweden, 3 Folkhalsan Genetic Institute, Folkhalsan Research Center, Biomedicum, Helsinki and
Malmska Municipal Health Care Center and Hospital, Jakobstad, Finland, 4 Department of Medicine, Helsinki University Central Hospital, University of
Helsinki, Finland, 5 Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland
Background. The muscle glycogen synthase gene (GYS1) has been associated with type 2 diabetes (T2D), the metabolic
syndrome (MetS), male myocardial infarction and a defective increase in muscle glycogen synthase protein in response to
exercise. We addressed the questions whether polymorphism in GYS1 can predict cardiovascular (CV) mortality in a high-risk
population, if this risk is influenced by gender or physical activity, and if the association is independent of genetic variation in
nearby apolipoprotein E gene (APOE). Methodology/Principal Findings.
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