原创力文档variable fitness impact of hiv-1 escape mutations to cytotoxic t lymphocyte (ctl) response变量健身影响hiv - 1逃避突变的细胞毒性t淋巴细胞(ctl)反应.pdfVIP
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variable fitness impact of hiv-1 escape mutations to cytotoxic t lymphocyte (ctl) response变量健身影响hiv - 1逃避突变的细胞毒性t淋巴细胞(ctl)反应
Variable Fitness Impact of HIV-1 Escape Mutations to
Cytotoxic T Lymphocyte (CTL) Response
1 2 3 4 1 1
Ryan M. Troyer , John McNevin , Yi Liu , Shao Chong Zhang , Randall W. Krizan , Awet Abraha ,
1 3 1,5 6 2 4
Denis M. Tebit , Hong Zhao , Santiago Avila , Michael A. Lobritz , M. Juliana McElrath , Sylvie Le Gall ,
3 1
James I. Mullins , Eric J. Arts *
1 Division of Infectious Diseases, Department of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, 2 Vaccine and Infectious Disease
Institute, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, 3 Department of Microbiology, University of
Washington, Seattle, Washington, United States of America, 4 Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston,
Massachusetts, United States of America, 5 National Institute of Respiratory Diseases, Center for Research in Infectious Diseases, Mexico City, Mexico, 6 Department of
Molecular and Microbiology, Case Western Reserve University, Cleveland, Ohio, United States of America
Abstract
Human lymphocyte antigen (HLA)-restricted CD8+ cytotoxic T lymphocytes (CTL) target and kill HIV-infected cells expressing
cognate viral epitopes. This response selects for escape mutations within CTL epitopes that can diminish viral replication
fitness. Here, we assess the fitness impact of escape mutations emerging in seven CTL epitopes in the gp120 Env and p24
Gag coding regions of an individual followed longitudinally from the time of
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