versatile roles of v-atpases accessory subunit ac45 in osteoclast formation and function多才多艺的角色v-atpases附属单元ac45破骨细胞形成和功能.pdfVIP

Versatile Roles of V-ATPases Accessory Subunit Ac45 in Osteoclast Formation and Function 1,2. 2. 2,3 2 4,5 6 1,7 An Qin , Tak S. Cheng , Zhen Lin , Nathan J. Pavlos , Qing Jiang , Jiake Xu , Ke R. Dai *, Ming H. Zheng2,4* 1 Shanghai Key Laboratory of Orthopaedic Implant, Department of Orthopaedics, Shanghai Jiao Tong University School of Medicine, Ninth People’s Hospital, Shanghai, The People’s Republic of China, 2 Centre for Orthopaedic Research, School of Surgery, The University of Western Australia, Perth, Australia, 3 Division of Orthopaedic, Department of Surgery, Guangdong Academy of Medical Sciences, Guangdong General Hospital, Guangdong, The People’s Republic of China, 4 Australian-China Joint Centre for Bone and Joint Research, Model Animal Research Centre of Nanjing University, Nanjing, The People’s Republic of China, 5 The Center of Diagnosis and Treatment for Joint Disease, Drum Tower Hospital Affiliated to Medical School of Nanjing University, Nanjing, The People’s Republic of China, 6 School of Pathology and Laboratory Medicine, The University of Western Australia, Perth, Australia, 7 Orthopaedic Cellular and Molecular Biology Laboratory, Institute of Health Sciences, School of Medicine, Chinese Academy of Sciences, Shanghai Jiao Tong University, Shanghai, The People’s Republic of China Abstract + Vacuolar-type H -ATPases (V-ATPases) are macromolecular proton pumps that acidify intracellular cargos and deliver protons across the plasma membrane of a variety of specialized cells, including bone-resorbing osteoclasts. Extracellular acidification is crucial for osteoclastic bone resorption, a process that initiates the dissolution of mine