updating fearful memories with extinction training during reconsolidation a human study using auditory aversive stimuli更新恐惧记忆灭绝训练在重塑人类研究使用听觉厌恶刺激.pdfVIP

Updating Fearful Memories with Extinction Training during Reconsolidation: A Human Study Using Auditory Aversive Stimuli ´ 1,2 1,2 ´ 1 1 3 Javiera P. Oyarzun , Diana Lopez-Barroso , Lluıs Fuentemilla , David Cucurell , Carmen Pedraza , Antoni Rodriguez-Fornells1,2,4, Ruth de Diego-Balaguer 1,2,4* 1 Cognition and Brain Plasticity Group, Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain, 2 Department of Basic Psychology, University of Barcelona, ´ ´ Barcelona, Spain, 3 Department of Psychobiology, Faculty of Psychology, University of Malaga, Malaga, Spain, 4 Catalan Institution for Research and Advanced Studies (ICREA), Barcelona, Spain Abstract Learning to fear danger in the environment is essential to survival, but dysregulation of the fear system is at the core of many anxiety disorders. As a consequence, a great interest has emerged in developing strategies for suppressing fear memories in maladaptive cases. Recent research has focused in the process of reconsolidation where memories become labile after being retrieved. In a behavioral manipulation, Schiller et al., (2010) reported that extinction training, administrated during memory reconsolidation, could erase fear responses. The implications of this study are crucial for the possible treatment of anxiety disorders without the administration of drugs. However, attempts to replicate this effect by other groups have been so far unsuccessful. We sought out to reproduce Schiller et al., (2010) findings in a different fear conditioning paradigm