vocal responses to perturbations in voice auditory feedback in individuals with parkinsons disease声音对扰动的反应在语音听觉反馈个人与帕金森症.pdfVIP

Vocal Responses to Perturbations in Voice Auditory Feedback in Individuals with Parkinson’s Disease 1 2 3 4 Hanjun Liu , Emily Q. Wang , Leo Verhagen Metman , Charles R. Larson * 1 Department of Rehabilitation Medicine, The First Affiliated Hospital, Sun Yat-sen University Guangzhou, People’s Republic of China, 2 Departments of Communication Disorders and Sciences, and Otolaryngology, Rush University Medical Center, Chicago, Illinois, United States of America, 3 Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America, 4 Department of Communication Science and Disorders, Northwestern University, Evanston, Illinois, United States of America Abstract Background: One of the most common symptoms of speech deficits in individuals with Parkinson’s disease (PD) is significantly reduced vocal loudness and pitch range. The present study investigated whether abnormal vocalizations in individuals with PD are related to sensory processing of voice auditory feedback. Perturbations in loudness or pitch of voice auditory feedback are known to elicit short latency, compensatory responses in voice amplitude or fundamental frequency. Methodology/Principal Findings: Twelve individuals with Parkinson’s disease and 13 age- and sex- matched healthy control subjects sustained a vowel sound (/a/) and received unexpected, brief (200 ms) perturbations in voice loudness ( 63 or 6 dB) or pitch ( 6100 cents) auditory feedback. Results showed that, while all subjects produced compensatory responses in their voice amplitude or fundamental frequency, individuals with PD exhibited larger response magnitudes than the control subjects. Furthermore, for loudness-shifted feedback, upward