原创力文档volatile organic compounds enhance allergic airway inflammation in an experimental mouse model挥发性有机化合物增强过敏性气道炎症实验小鼠模型.pdfVIP
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volatile organic compounds enhance allergic airway inflammation in an experimental mouse model挥发性有机化合物增强过敏性气道炎症实验小鼠模型
Volatile Organic Compounds Enhance Allergic Airway
Inflammation in an Experimental Mouse Model
¨ 1,2 ¨ 1 3 ¨ 1 ¨ 1,2
Ulrike Bonisch , Alexander Bohme , Tibor Kohajda , Iljana Mogel , Nicole Schutze , Martin von
3 2 1 1,2
Bergen , Jan C. Simon , Irina Lehmann , Tobias Polte *
1 Department of Environmental Immunology, UFZ – Helmholtz Centre for Environmental Research Leipzig-Halle, Leipzig, Germany, 2 Department of Dermatology,
Venerology and Allergology, Leipzig University Medical Center, University of Leipzig, Leipzig, Germany, 3 Department of Metabolomics, UFZ – Helmholtz Centre for
Environmental Research Leipzig-Halle, Leipzig, Germany
Abstract
Background: Epidemiological studies suggest an association between exposure to volatile organic compounds (VOCs) and
adverse allergic and respiratory symptoms. However, whether VOCs exhibit a causal role as adjuvants in asthma
development remains unclear.
Methods: To investigate the effect of VOC exposure on the development of allergic airway inflammation Balb/c mice were
exposed to VOCs emitted by new polyvinylchloride (PVC) flooring, sensitized with ovalbumin (OVA) and characterized in
acute and chronic murine asthma models. Furthermore, prevalent evaporated VOCs were analyzed and mice were exposed
to selected single VOCs.
Results: Exposure of mice to PVC flooring increased eosinophilic lung inflammation and OVA-specific IgE serum levels
compared to un-exposed control mice. The increased inflamma
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