原创力文档valsartan improves adipose tissue function in humans with impaired glucose metabolism a randomized placebo-controlled double-blind trial缬沙坦与葡萄糖代谢改善脂肪组织功能在人类一项随机安慰剂对照双盲试验.pdfVIP
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valsartan improves adipose tissue function in humans with impaired glucose metabolism a randomized placebo-controlled double-blind trial缬沙坦与葡萄糖代谢改善脂肪组织功能在人类一项随机安慰剂对照双盲试验
Valsartan Improves Adipose Tissue Function in Humans
with Impaired Glucose Metabolism: A Randomized
Placebo-Controlled Double-Blind Trial
1 1 2 3 3
Gijs H. Goossens *, Chantalle C. M. Moors , Nynke J. van der Zijl , Nicolas Venteclef , Rohia Alili ,
1 1 4 ´ 3 2
Johan W. E. Jocken , Yvonne Essers , Jack P. Cleutjens , Karine Clement , Michaela Diamant ,
Ellen E. Blaak1
1 Department of Human Biology, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Center, Maastricht, The Netherlands, 2 Diabetes
Center, Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands, 3 INSERM, Nutriomique U872 (Eq 7), University Pierre et Marie Curie-
ˆ ´ ˆ `
Paris 6, Cordelier Research Center, Human Nutrition Research Center; Assistance Publique-Hopitaux de Paris, Pitie-Salpetriere hospital, Paris, France, 4 Department of
Pathology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Center, Maastricht, The Netherlands
Abstract
Background: Blockade of the renin-angiotensin system (RAS) reduces the incidence of type 2 diabetes mellitus. In rodents, it
has been demonstrated that RAS blockade improved adipose tissue (AT) function and glucose homeostasis. However, the
effects of long-term RAS blockade on AT function have not been investigated in humans. Therefore, we examined whether
26-wks treatment with the angiotensin II type 1 receptor blocker valsartan affects AT function in humans with impaired
glucose metabolism (IGM).
Meth
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