depletion of cellular pre-replication complex factors results in increased human cytomegalovirus dna replication损耗的细胞pre-replication复杂因素导致增加人类巨细胞病毒dna复制.pdfVIP

Depletion of Cellular Pre-Replication Complex Factors Results in Increased Human Cytomegalovirus DNA Replication Tamara Evans Braun., Emma Poole., John Sinclair* Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, United Kingdom Abstract Although HCMV encodes many genes required for the replication of its DNA genome, no HCMV-encoded orthologue of the origin binding protein, which has been identified in other herpesviruses, has been identified. This has led to speculation that HCMV may use other viral proteins or possibly cellular fac