drosophila melanogaster as a model organism of brain diseases黑腹果蝇作为模式生物的大脑疾病.pdfVIP

Int. J. Mol. Sci. 2009, 10, 407-440; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Drosophila melanogaster as a Model Organism of Brain Diseases Astrid Jeibmann * and Werner Paulus Institute of Neuropathology, Domagkstraße 19, 48149 Münster, University Hospital Münster, Germany * Author to whom correspondence should be addressed; E-Mail: jeibmann@uni-muenster.de; Tel. +49-251 83 57549; Fax: +49-251 83 56971 Received: 30 December 2008; in revised form: 16 January 2009 / Accepted: 20 January 2009 / Published: 2 February 2009 Abstract: Drosophila melanogaster has been utilized to model human brain diseases. In most of these invertebrate transgenic models, some aspects of human disease are reproduced. Although investigation of rodent models has been of significant impact, invertebrate models offer a wide variety of experimental tools that can potentially address some of the outstanding questions underlying neurological disease. This review considers what has been gleaned from invertebrate models of neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, metabolic diseases such as Leigh disease, Niemann-Pick disease and ceroid lipofuscinoses, tumor syndromes such as neurofibromatosis and tuberous sclerosis, epilepsy as well as CN