ectopic expression of aid in a non-b cell line triggers a∶t and gc point mutations in non-replicating episomal vectors异位表达的援助non-b细胞系触发∶t和gc non-replicating游离向量的点突变.pdfVIP
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ectopic expression of aid in a non-b cell line triggers a∶t and gc point mutations in non-replicating episomal vectors异位表达的援助non-b细胞系触发∶t和gc non-replicating游离向量的点突变
Ectopic Expression of AID in a Non-B Cell Line Triggers
A:T and G:C Point Mutations in Non-Replicating Episomal
Vectors
´
Tihana Jovanic, Benjamin Roche, Geraldine Attal-Bonnefoy, Olivier Leclercq, Franc¸ois Rougeon*
´ ´ ´ ´ ´
Unite de Genetique et Biochimie du Developpement, Departement d’Immunologie, URA CNRS 2581, Institut Pasteur, Paris, France
Somatic hypermutation (SHM) of immunoglobulin genes is currently viewed as a two step process initiated by the deamination
of deoxycytidine (C)
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