117环氧化酶在脊髓痛觉调制中的作用（The role of 117 cyclooxygenase in spinal nociceptive modulation）.doc

117环氧化酶在脊髓痛觉调制中的作用（The role of 117 cyclooxygenase in spinal nociceptive modulation） The role of cyclooxygenase in spinal horizontal pain modulation and the clinical application of inhibitors Jiangsu Key Laboratory of anesthesia Graduate student of Grade 2004: Gong Qin Advisor: Prof. Hu Xingguo Prof. Zeng Zeng Cyclooxygenase (cyclooxygenase, COX) or prostaglandin H synthase (PGHs) is four arachidonic acid metabolism, prostaglandin (PROTAGLANDIN, PG) and thromboxane A2 (TXA2) is one of the important rate limiting enzyme in the biosynthesis of. Many studies have shown that COX may play an important role in pain information processing in the spinal cord. In this paper, the research situation in this field is reviewed. Biochemical and pharmacological properties of 1 COX 1.1 COX and PGs Four arachidonic acid is a kind of animal feeding PGs precursors mainly, through the PLA2 and PLC on the cell membrane phospholipids, four arachidonic acid by catalyzing the formation of COX PGG2, which is then converted to PGH2, PGs and PGH2 compounds generated further synthase and coagulation in various isomerase prostacyclin synthase were evil action, including an important function of PGs and thromboxane. Studies have shown that PGs may play an important role in triggering and maintaining nociception, and it is an important proinflammatory and pain molecule. 1.2 COX molecules COX COX-1 and COX-2 two subtypes, COX-1 normally exist in normal cells, called structural COX, mediated physiological reaction; COX-2 may be expressed in cytokines, growth factors and inflammatory factors stimulating, which is called by COX. Recently, Chandrasekharan[1] et al reported that there are subtypes of COX-3 in nerve tissue, which later proved that COX-3 is actually COX-1v, but there is still a lack of understanding of COX-1v. COX-1 and COX-2 are membrane associated enzymes, the molecular weight of 71KD, the molecule contains a long narrow pipe structure, pipe end structure is a slightly raised blind shor