药理学重点_期末考试用（Key _ final exam for Pharmacology）.docVIP

药理学重点_期末考试用（Key _ final exam for Pharmacology） Key _ final exam for Pharmacology I. noun interpretation The in vivo process of drug absorption (drug use drug to enter blood circulation) - distribution (drug absorption from the blood circulation to the body and all parts of the organization) -- an important way of drug metabolism (as a foreign body into the body, the body to mobilize various mechanisms. The drug elimination from the body, the elimination of drug metabolism is from the body) - (mainly via urine excretion, followed by feces, volatile by lung, sweat and milk is excreted) First pass elimination: from the gastrointestinal absorption of drugs in the portal vein system reaches the systemic circulation through the liver before, if the liver is very strong on the metabolism, or by biliary excretion volume, the effective amount of drugs into the systemic circulation significantly reduced this effect, said. Blood brain barrier: the brain capillary endothelial cells are closely linked, without gaps between endothelial cells and capillaries, the outer surface is almost surrounded by astrocytes, the special structure formed between the plasma and cerebrospinal fluid barrier, called. Enterohepatic circulation: in bile is secreted into the drug and its metabolites through the bile duct and common bile duct into the intestinal lumen, and then excreted in the stool out after drug bile into the intestinal cavity partially by intestinal epithelial cells and then absorbed into the blood circulation through the liver, the liver, bile, intestinal cycle between said ~. Primary elimination kinetics: the percentage of drugs in the body that is eliminated in unit time, i.e., the amount of drugs removed in a unit time is proportional to the concentration of the plasma. The first order kinetic process is also called linear dynamic process. Zero elimination kinetics: drugs are eliminated at a constant rate in the body, i.e., regardless of the level of plasma concentration, the am