中心复合设计法优化秋水仙碱双层片处方的研究.PDF

7 0 中草药 Chinese Traditional and Herbal Drugs 4 5 20 0 5 1, 2 2 1 1* 1 何元田 , 刘 文 , 刘 姹 , 杨大坚 , 周 伟 ( 1 , 518057; 2 , 550002) : , , , , H PMC k 15PEO700 1~ 12 h , 12 h 90% : ; ; ; : R2842; R286. 02 : A : 2010) Formulation optimization of colchicines doublelayer tablet by central composite design 1, 2 2 1 1 1 HE Yu nti n , LIU Wen , LIU Ch , YANG D ji n , ZHOU Wei ( 1 St t e Key L bor tory of Chinese Medicine nd Molecul r Ph rm cology Inst itute of Modern Chinese Medicine, H ong Kong Polytechnic University , Shenzhen 518057, Chin ; 2 Guiy ng College of T r dition l Chinese Medicine, Guiy ng 550002, Chin ) Abstract: Objective To investig te the optim l formul tion nd drug rele se profile of colchicine double l yer t blets Methods T he key influencing f ctors nd optim l formul tion w ere studied b sed on the cu mul tive drug r ele se r te t different time points nd homogenous f ctor (f 2 ) nd optimiz tion of the for mul tion by centr l composite design Results T he drug rele se profile inv itro w s influenced by mount of HPM C k 15 nd PEO700 The optim l in v itro drug rele se profile presented extendedrele se ch r cter signific ntly w ithin 1- 12 h, nd drug r ele sed t 12 h re ched more th n 90% Conclusion T he method is suit ble to optimize the formul tion of colchicine doublel yer t blets Key words: colchicine; doublel y er t blet; homogenous f ctor; centr l composite design ( colchicine) 1763 , ,