雅博司在肝癌手术中对肝功能保护作用.docVIP

雅博司在肝癌手术中对肝功能保护作用 　 作者;苏才坤，甄宇洋，周奇，李守智 ［摘要］ 目的 探讨雅博司在肝癌手术中对肝功能的保护作用。方法 试验组24例，在肝癌切除手术中经过门静脉使用雅博司作为主要护肝药物。对照组26例，外周静脉使用常规护肝药物。两组病人检测术后肝功能的变化及了解术后并发症等。结果 术后第1天AST及术后第7天TB、AST、ALT、ALB，试验组与对照组的比较差异有显著性（Plt;0.05）。对照组术后肝昏迷有2例，两组病人均无发生上消化道出血、肝肾综合征。无手术死亡病例。结论 雅博司在肝癌手术中对肝功能有显著的保护作用。 ［关键词］ 肝癌；肝功能；肝切除术；雅博司 Evaluation of Lornithine Laspartate application in hepatectomy prot ection ［Abstract］ Objective To evaluate the role of prevention of LornithineLaspartate application in hepatectomy.Methods 50 hepatocellular carcinoma cases who had hepatectomy were randomly divided into treatment group (LornithineLaspartate group) and control group.LornithineLaspartate were injected from port vein in 24 cases of treatment group in 7 days from operation day to 7th day after operation addition to routine treatment；26 cases of control group were treated by routine protocols at the same time.TBIL，AST，ALT and ALB were detected at the time points of before operation，1st day and 7th day after operation.Results ALT in 1st day after operation was lower in treatment group compared with that in control.TBIL，AST and ALT in 7th day after operation were all lower significantly in treatment group when compared with control (Plt;0.05).ALB Plasma levels in 7th day after operation was higher in treatment group than that in control (Plt;0.05).Conclusion LornithineLaspartate application by vein bolus had protective affect with hepatic function after hepatectomy in HCC patients. ［Key words］ hepatocellular carcinoma；liver function；hepatectomy；LornithineLaspartate 我院于2001年1月～2004年12月在肝癌切除术中经过门静脉使用雅博司作为主要护肝药物。以24例肝癌病人作为主要研究对象（试验组），与同期另一手术治疗组在肝癌切除手术中只使用护肝药物26例为对照（对照组）。从初步结果分析，雅博司在肝切除手术中对肝功能有显著的保护作用。现报告如下。 1 资料与方法 1.1 一般资料 试验组24例，男20例，女4例；年龄最大66岁，最小31岁，平均45岁。对照组26例，男21例，女5例；年龄最大68岁，最小34岁，平均48岁。试验组合并肝硬化20例，对照组合并肝 硬化21例，两组肝功能情况见表1。两组肝硬化情况差异无显著性。手术方式：试验组，肝叶切除10例，左半肝切除8例，右半肝切除6例。对照组，肝叶切除11例，左半肝切除7例，右半肝切除8例。 表1 试验组与对照组肝功能情况比较 （例） 1.2 方法 试验组24例，在肝癌切除手术前将导管通过结肠中静脉插管到门静脉并于皮下埋藏灌注器，在肝切除手术过程中