利培酮氯丙嗪对首发精神分裂症患者眼动分析NEF影响.docVIP

利培酮氯丙嗪对首发精神分裂症患者眼动分析NEF影响 　 作者：石玉中 王亚丽 李荣娓 孙伟力 任文林 【摘要】 　　目的 探讨眼动分析中凝视点数和反应性探索分析能否作为首发精神分裂症患者的诊断和治疗效果的客观依据以及这两种指标是否受不同抗精神病药物治疗的影响。 方法 将符合入组标准的53例精神分裂症患者随机分为氯丙嗪组24例、利培酮组29例进行治疗，疗程6 w。随机抽取30例正常健康者为对照组，于患者组治疗前及治疗6 w末测评三组眼动分析中凝视点数来分析其认知功能的改善情况。 结果 氯丙嗪组、利培酮组眼动分析中凝视点数评分均显著低于对照组（P＜0.01），治疗6 w末凝视点数评分虽有显著升高（P＜0.01），但仍均显著低于对照组，差异均有极显著性（P＜0.01）。 结论 凝视点数测评可作为首发精神分裂症患者诊断和判定疗效的客观依据，并且可能受药物的影响。 【关键词】 首发精神分裂症；NEF；利培酮；氯丙嗪 　　　【Abstract】 Objective To explore whether the NEF and RSS in exploratory eye movement could be regarded as objective evidences for diagnosis and curative effects of the firstepisode schizophrenics and be influenced by different antipsychotics. Methods 53 schizophrenics fitting recruitment criteria were randomly divided into chlorpromazine(n=24) and risperidone(n=29) group for 6 weeks，randomly selected 30 normal healthy persons were as control group. The NEF was measured to analyze the improvements of cognitive function before treatment and at the end of the 6th week treatment. Results NEF scores of both chlorpromazine and risperidone groups were significantly lowere than those of control group(Plt;0.01)；at the end of the 6th week although those increased significantly(Plt;0.01)，yet were lower compared with control group，difference was very significant(Plt;0.01). Conclusion NEF measurements may be regarded as objective evidences for diagnosis and deciding curative effects and are possibly influenced by drugs；supplementary target and therapentic efficacy to the firstepisode schizophrenia. And that they are maybe influenced by drugs treatment. Meanwhile，the research show that Risperidone group is no more than chlorpromazine group in improving cognitive function of the firstepisode schizophrenia. 　　【Keywords】 Firstepisode schizophrenia；NEF；risperidone；chlorpromazine 　　精神分裂症患者均存在认知功能障碍，而认知功能主要包括注意、记忆、抽象思维、信息整合以及执行功能等方面。感知周期理论认为视觉认知过程中包括预期和确认，关键是预期阶段，人们准备接受某种特定的信息，从而控制人们的注视行为，预期阶段指导了眼球的探索过程，人们常主动的移动眼球和头部来观察物体，希望从图形中得到更多的信息。 　　目前世界上关于眼球运动的研究有两种：一是美国Holzman提出的平稳眼跟