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the pafah1b complex interacts with the reelin receptor vldlrreelin受体vldlr pafah1b复杂的相互作用.pdf

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the pafah1b complex interacts with the reelin receptor vldlrreelin受体vldlr pafah1b复杂的相互作用

The Pafah1b Complex Interacts with the Reelin Receptor VLDLR 1,2. 1,2. 1,2 7 8 7 1,2,3,4. Guangcheng Zhang , Amir H. Assadi , Robert S. McNeil , Uwe Beffert , Anthony Wynshaw-Boris , Joachim Herz , Gary D. Clark , Gabriella D’Arcangelo1,2,3,5,6.* 1The Cain Foundation Laboratories, Texas Children’s Hospital, Houston, Texas, United States of America, 2 Department of Pediatrics, Baylor College of Medicine, Houston, Texas, United States of America, 3 Department of Neuroscience, Baylor College of Medicine, Houston, Texas, United States of America, 4 Department of Neurology, Baylor College of Medicine, Houston, Texas, United States of America, 5 Program in Developmental Biology, Baylor College of Medicine, Houston, Texas, United States of America, 6 Program in Translational Biology and Molecular Medicine, Baylor College of Medicine, Houston, Texas, United States of America, 7 Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, 8 Department of Pediatrics and Medicine, University of California, San Diego School of Medicine, La Jolla, California, United States of America Reelin is an extracellular protein that directs the organization of cortical structures of the brain through the activation of two receptors, the very low-density lipoprotein receptor (VLDLR) and the apolipoprotein E receptor 2 (ApoER2), and the phosphorylation of Disabled-1 (Dab1). Lis1, the product of the Pafah1b1 gene, is a component of the brain platelet-activating factor acetylhydrolase 1b (Pafah1b) complex, and binds to phosphorylated Dab1 in response to Reelin. Here we investigated the involvement of the whole Pafah1b complex in Reelin signaling and cortical layer formation and