原创力文档the polycomb repressive complex 2 is a potential target of sumo modificationspolycomb专制复杂的2是一个潜在的目标相扑的修改.pdfVIP
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the polycomb repressive complex 2 is a potential target of sumo modificationspolycomb专制复杂的2是一个潜在的目标相扑的修改
The Polycomb Repressive Complex 2 Is a Potential Target
of SUMO Modifications
1,2 3¤ 3 1,2 1,2
Eva Madi Riising , Roberto Boggio , Susanna Chiocca , Kristian Helin *, Diego Pasini
1 Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark, 2 Centre for Epigenetics, University of Copenhagen, Copenhagen,
Denmark, 3 Department of Experimental Oncology, European Institute of Oncology, Milan, Italy
Abstract
Background: The Polycomb Repressive Complex 2 (PRC2) functions as a transcriptional repressor through a mechanism that
involves methylation of Histone H3 at lysine 27. The PRC2 complex activity is essential for cellular proliferation,
development, and cell fate decisions. PRC2 target genes include important regulators of development and proliferation as
well as tumor suppressor genes. Consistent with this, the activity of several Polycomb group (PcG) proteins is deregulated in
human cancer suggesting an important role for PcGs in tumor development. Whereas the downstream functions of PcGs
are well characterized, the mechanisms of their recruitment to target genes and the regulation of their activity are not fully
understood.
Principal Findings: Here we show that the two PRC2 components SUZ12 and EZH2 are sumoylated in vitro and in vivo.
Among several putative sumoylation sites we have mapped the major site of SUZ12 sumoylation. Furthermore, we show
that SUZ12 interacts with the E2-conjugating enzyme UBC9 both in vitro and in vivo and that mutation of the SUZ12
sumoylation site does not abolish this binding. Finally, we provide evidence that the E3-ligase PIASXb interacts and
enhances the sumoylation of SUZ12 i
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