the potential for resident lung mesenchymal stem cells to promote functional tissue regeneration understanding microenvironmental cues潜在的居民肺间充质干细胞促进功能性组织再生微环境线索理解.pdfVIP
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the potential for resident lung mesenchymal stem cells to promote functional tissue regeneration understanding microenvironmental cues潜在的居民肺间充质干细胞促进功能性组织再生微环境线索理解
Cells 2012, 1, 874-885; doi:10.3390/cells1040874
OPEN ACCESS
cells
ISSN 2073-4409
/journal/cells
Review
The Potential for Resident Lung Mesenchymal Stem Cells to
Promote Functional Tissue Regeneration: Understanding
Microenvironmental Cues
Robert F. Foronjy 1 and Susan M. Majka 2,*
1 Antenucci Building,
432 West 58th Street, Room 311, New York, NY 10019, USA; E-Mail: rforonjy@;
Tel.: +1-212-523-7265
2 Department of Medicine, Vanderbilt University, 1161 21st. Ave S, T1218 MCN, Nashville,
TN 37232, USA
* Author to whom correspondence should be addressed; E-Mail: susan.m.majka@V;
Tel.: +1-303-883-8786.
Received: 28 August 2012; in revised form: 19 September 2012 / Accepted: 25 September 2012 /
Published: 19 October 2012
Abstract: Tissue resident mesenchymal stem cells (MSCs) are important regulators of
tissue repair or regeneration, fibrosis, inflammation, angiogenesis and tumor formation.
Bone marrow derived mesenchymal stem cells (BM-MSCs) and endothelial progenitor
cells (EPC) are currently being considered and tested in clinical trials as a potential therapy
in patients with such inflammatory lung diseases including, but not limited to, chronic lung
disease, pulmonary arterial hypertension (PAH), pulmonary fibrosis (PF), chronic
obstructive pulmonary disease (COPD)/emphysema and asthma. However, our current
understanding of tissue resident lung MSCs remains limited. This review addresses how
environmental cues
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