the potential of human regulatory t cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases人类的潜力调节性t细胞体外生成用于治疗红斑狼疮和其他慢性炎性疾病.pdfVIP

Available online /content/4/4/241 Commentary The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases David A Horwitz, J Dixon Gray and Song Guo Zheng The Division of Rheumatology and Immunology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA Corresponding author: David A Horwitz (e-mail: dhorwitz@) Received: 5 December 2001 Revisions received: 1 February 2002 Accepted: 7 February 2002 Published: 12 March 2002 Arthritis Res 2002, 4:241-246 © 2002 BioMed Central Ltd (Print ISSN 1465-9905; Online ISSN 1465-9913) Abstract Regulatory T cells prevent autoimmunity by suppressing the reactivity of potentially aggressive self- reactive T cells. Contact-dependent CD4+ CD25+ ‘professional’ suppressor cells and other cytokine- producing CD4+ and CD8+ T-cell subsets mediate this protective function. Evidence will be reviewed that T cells primed with transforming growth factor (TGF)-β expand rapidly following restimulation. Certain CD4+ T cells become contact-dependent suppressor cells and other CD4+ and CD8+ cells become cytokine-producing regulatory cells. This effect is dependent upon a sufficient amount of IL-2 in the microenvironment to overcome the suppressive effects of TGF-β. The adoptive transfer of these suppressor cells generated ex vivo can protect mice from developing chronic graft versus host disease with a lupus-like syndrome and alter the course of established disease. These data suggest that autologous T cells primed and expanded with TGF-β have the potential to be used