the power of exercise buffering the effect of chronic stress on telomere length的力量锻炼缓冲慢性应激对端粒长度的影响.pdfVIP

The Power of Exercise: Buffering the Effect of Chronic Stress on Telomere Length 1 2 2 1,3 1 1 Eli Puterman *, Jue Lin , Elizabeth Blackburn , Aoife O’Donovan , Nancy Adler , Elissa Epel 1 Department of Psychiatry, University of California San Francisco, San Francisco, California, United States of America, 2 Department of Biochemistry and Biophysics, University of California San Francisco, San Francisco, California, United States of America, 3 Veterans Affairs Medical Center, San Francisco, California, United States of America Abstract Background: Chronic psychological stress is associated with detrimental effects on physical health, and may operate in part through accelerated cell aging, as indexed by shorter telomeres at the ends of chromosomes. However, not all people under stress have distinctly short telomeres, and we examined whether exercise can serve a stress-buffering function. We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening. Methodology and Principal Findings: 63 healthy post-menopausal women underwent a fasting morning blood draw for whole blood TL analysis by a quantitative polymerase chain reaction method. Participants completed the Perceived Stress Scale (Cohen et al., 1983), and for three successive days reported daily minutes of vigorous activity. Participants were categorized into two groups-sedentary and active (those getting Centers for Disease Control-recommended daily amount of activity). The likelihood of having short versus long telomeres was calculated as a fu