原创力文档the power of two experimental designs for detecting linkage between a marker locus and a locus affecting a quantitative character in a segregating population两个实验设计用于检测的力量之间的联系一个标记位点和轨迹影响人口数量性状在隔离.pdfVIP
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the power of two experimental designs for detecting linkage between a marker locus and a locus affecting a quantitative character in a segregating population两个实验设计用于检测的力量之间的联系一个标记位点和轨迹影响人口数量性状在隔离
Original article
The of two
power experimental designs
for detecting linkage between a marker
locus and a locus affecting
a quantitative character
in a segregating population
ZW Luo
University of Edinbu!gh, Institute of Cell Animal and Population
Biology, King’s Buildings, Edinburgh EH 9 .!JT, UK
(Received 14 November 1991; accepted 9 February 1993)
Summary - The statistical power of 2 experimental designs (backcrossing and intercross-
ing) for detecting linkage between a marker gene and a quantitative trait locus (QTL)
in families derived from a segregating population is investigated. Formulae which relate
to the recombination between the the of
power frequency (r) genes, genetical properties
the quantitative trait controlled by the QTL and the design parameters are developed.
The reliability of some simplifying assumptions was confirmed by computer simulations.
Application of these formulae has shown that the power of the 2 designs with population
size of 1 000 was 20% when r was 0.3 for all heritabilities of single gene considered,
few large families are better than many small families, and backcrossing is generally more
efficient than intercrossing. The allele frequencies and dominance properties of the QTLs
have interactions in their effects on
important power.
statistical power / marker - QTL linkage / backcross / intercross
Résumé - Puissance de 2 plans d’expérience pour détecter une liaison génétique entre
un locus marqueur et un locus influençant un caractère quantitatif dans une popu-
lation en ségré
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