the presence of il-17a and t helper 17 cells in experimental mouse brain tumors and human gliomail-17a和17辅助t细胞在实验老鼠脑部肿瘤和人类神经胶质瘤.pdfVIP
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the presence of il-17a and t helper 17 cells in experimental mouse brain tumors and human gliomail-17a和17辅助t细胞在实验老鼠脑部肿瘤和人类神经胶质瘤
The Presence of IL-17A and T Helper 17 Cells in
Experimental Mouse Brain Tumors and Human Glioma
Derek A. Wainwright, Sadhak Sengupta, Yu Han, Ilya V. Ulasov, Maciej S. Lesniak*
The Brain Tumor Center, The University of Chicago, Chicago, Illinois, United States of America
Abstract
+ +
Background: Recently, CD4 IL-17A T helper 17 (Th17) cells were identified and reported in several diseased states,
including autoimmunity, infection and various peripheral nervous system tumors. However, the presence of Th17 in glia-
derived tumors of the central nervous system has not been studied.
Methodology/Principal Findings: In this report, we demonstrate that mRNA expression for the Th17 cell cytokine IL-17A, as
well as Th17 cells, are present in human glioma. The mRNA expression for IL-17A in glioma was recapitulated in an
immunocompetent mouse model of malignant glioma. Furthermore, the presence of Th17 cells was confirmed in both
human and mouse glioma. Interestingly, some Th17 cells present in mouse glioma co-expressed the Th1 and Th2 lineage
markers, IFN-c and IL-4, respectively, but predominantly co-expressed the Treg lineage marker FoxP3.
Conclusions: These data confirm the presence of Th17 cells in glia-derived CNS tumors and provide the rationale for further
investigation into the role of Th17 cells in malignant glioma.
Citation: Wainwright DA, Sengupta S, Han Y, Ulasov IV, Lesniak MS (2010) The Presence of IL-17A and T Helper 17 Cells in Experimental Mouse Brain Tumors and
Human Glioma. PLoS ONE 5(10): e15390. doi:10.1371/journal.pone.0015390
Editor: Maria G. Castro, UCLA and Cedars-Sinai Medical Center, United States of America
Received August 10, 2010; Accepted August 20, 2010; Published October 23, 2010
Copyright: 2010 Wainwright et al. This is an open-acce
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