the protective effects of silymarin against doxorubicin-induced cardiotoxicity and hepatotoxicity in rats水飞蓟素的保护作用与doxorubicin-induced毒性,在大鼠肝毒性.pdfVIP

Molecules 2011, 16, 8601-8613; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article The Protective Effects of Silymarin against Doxorubicin-Induced Cardiotoxicity and Hepatotoxicity in Rats 1 1, 2 1 Aleksandar Rašković , Nebojša Stilinović *, Jovanka Kolarović , Velibor Vasović , Saša Vukmirović1 and Momir Mikov 1 1 Department of Pharmacology, Toxicology and Clinical Pharmacology, School of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia; E-Mails: araskovic@ (A.R.) vasovicv@ (V.V.); sasavukmirovic99@ (S.V.); momir.mikov@otago.ac.nz (M.M.) 2 Department of Hematology and Oncology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, 21000 Novi Sad, Serbia; E-Mail: jovanka.kolarovic@ (J.K.) * Author to whom correspondence should be addressed; E-Mail: nebojsa.stilinovic@; Tel.: +381-64-265-3688; Fax: +381-21-661-5771. Received: 7 September 2011; in revised form: 5 October 2011 / Accepted: 10 October 2011 / Published: 12 October 2011 Abstract: Silymarin is a complex of five major compounds, and silibinin is the most biologically active component of the complex. The aim of this study was to investigate, evaluate and confirm the potential cardioprotective and hepatoprotective effects of administration of silymarin, rich in silibinin, at a dose of 60 mg/kg orally for a time-span of 12 days on doxorubicin induced toxicity in m