原创力文档the proto-oncogene lrf is under post-transcriptional control of mir-20a implications for senescence原癌基因的探测器是转录后控制mir-20a对衰老的影响.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
the proto-oncogene lrf is under post-transcriptional control of mir-20a implications for senescence原癌基因的探测器是转录后控制mir-20a对衰老的影响
The Proto-Oncogene LRF Is under Post-Transcriptional
Control of MiR-20a: Implications for Senescence
1,2,3. 1. 1 1 2,3 1
Laura Poliseno , Letizia Pitto , Marcella Simili , Laura Mariani , Luisa Riccardi , Alessia Ciucci ,
1 1 1 2,3 1,4
Milena Rizzo , Monica Evangelista , Alberto Mercatanti , Pier Paolo Pandolfi , Giuseppe Rainaldi *
1 Laboratory of Gene and Molecular Therapy, Institute of Clinical Physiology, CNR, Pisa, Italy, 2 Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department
of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America, 3 Cancer Genetics Program, Beth Israel
Deaconess Cancer Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America,
4 Istituto Toscano Tumori, Firenze, Italy
Abstract
MicroRNAs (miRNAs) are short 20–22 nucleotide RNA molecules that act as negative regulators of gene expression via
translational repression: they have been shown to play a role in development, proliferation, stress response, and apoptosis.
The transcriptional regulator LRF (Leukemia/lymphoma Related Factor) has been shown to prevent p19ARF transcription
and consequently to inhibit senescence in mouse embryonic fibroblasts (MEF). Here we report, for the first time, that LRF is
post-transcriptionally regulated by miR-20a. Using a gene reporter assay, direct interaction of miR-20a with the LRF 39UTR is
demonstrated. To validate the
您可能关注的文档
- syntheses and biological activities of 6-aryl-3-(3-hydroxy- propyl)-7h-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines合成和生物活动6-aryl-3 - h - 7(3-hydroxy -丙基),2,4-triazolo[3、4 b][1,3,4]thiadiazines.pdf
- the origin and genetic variation of domestic chickens with special reference to junglefowls gallus g. gallus and g. varius国内鸡的起源和遗传变异与红原鸡背带g .背带和瓦瑞斯g.pdf
- the origin of glucocorticoid hormone oscillations糖皮质激素激素振荡的起源.pdf
- the origin of gpcrs identification of mammalian like rhodopsin, adhesion, glutamate and frizzled gpcrs in fungi哺乳动物的起源gpcrs识别像视紫红质,附着力、谷氨酸和卷曲的gpcrs真菌.pdf
- the origin of phenotypic heterogeneity in a clonal cell population in vitro表型异质性的起源在体外克隆的细胞群.pdf
- the origin of recent introns transposons最近的内含子的起源转座子.pdf
- the origin and early evolution of eukaryotes in the light of phylogenomics真核生物的起源和早期演化phylogenomics的光.pdf
- the origin of large molecules in primordial autocatalytic reaction networks的起源在原始大分子催化反应网络.pdf
- the origin of tc enhancement in heterostructure cuprate superconductorstc的起源在异质结构增强铜酸盐超导体.pdf
- the origin of the ‘mycoplasma mycoides cluster’ coincides with domestication of ruminantsu201c支原体mycoides集群u201d的起源与反刍动物的驯化.pdf
- the pseudokinase nipi-4 is a novel regulator of antimicrobial peptide gene expression的pseudokinase nipi-4抗菌肽基因表达的是一种新型的监管机构.pdf
- the pseudomonas aeruginosa autoinducer 3o-c12 homoserine lactone provokes hyperinflammatory responses from cystic fibrosis airway epithelial cells绿脓杆菌autoinducer 3 o-c12高丝氨酸内酯引发hyperinflammatory从囊性纤维化反应气道上皮细胞.pdf
- the pseudomonas aeruginosa reference strain pa14 displays increased virulence due to a mutation in lads铜绿假单胞菌参考应变pa14显示由于小伙子的突变增加毒性.pdf
- the p-ssp7 cyanophage has a linear genome with direct terminal repeats的p-ssp7噬藻体线性基因组末端直接重复.pdf
- the pseudomonas aeruginosa n-acylhomoserine lactone quorum sensing molecules target iqgap1 and modulate epithelial cell migration铜绿假单胞菌的n-acylhomoserine内酯群体感应分子目标iqgap1和调节上皮细胞迁移.pdf
- the proteomic profile of hereditary inclusion body myopathy遗传性包涵体肌病的蛋白质组学概要文件.pdf
- the psychiatric case register middle netherlands精神病案例注册荷兰中产.pdf
- the psycolaus study methodology and characteristics of the sample of a population-based survey on psychiatric disorders and their association with genetic and cardiovascular risk factorspsycolaus研究方法和样本的特征以人群为基础的调查精神疾病与遗传和心血管风险因素和他们的联系.pdf
- the ptpn22 1858ct polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern sweden1858年ptpn22 ct多态性与anti-cyclic citrullinated肽抗体阳性早期类风湿性关节炎在瑞典北部.pdf
- the psychometric properties of the subscales of the ghq-28 in a multi-ethnic maternal sample results from the born in bradford cohort的心理属性分量表的ghq-28多民族母亲出生在布拉德福德的队列的示例结果.pdf
文档评论（0）