原创力文档the ptpn22 1858ct polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern sweden1858年ptpn22 ct多态性与anti-cyclic citrullinated肽抗体阳性早期类风湿性关节炎在瑞典北部.pdfVIP
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the ptpn22 1858ct polymorphism is associated with anti-cyclic citrullinated peptide antibody-positive early rheumatoid arthritis in northern sweden1858年ptpn22 ct多态性与anti-cyclic citrullinated肽抗体阳性早期类风湿性关节炎在瑞典北部
Available online /content/9/3/R56
Vol 9 No 3 Open Access
Research article
The PTPN22 1858C/T polymorphism is associated with anti-cyclic
citrullinated peptide antibody-positive early rheumatoid arthritis
in northern Sweden
1 1 1 2 1
Heidi Kokkonen , Martin Johansson , Lena Innala , Erik Jidell and Solbritt Rantapää-Dahlqvist
1Department of Rheumatology, University Hospital, SE-901 85 Umeå, Sweden
2Department of Transfusion Medicine, University Hospital, SE-901 85 Umeå, Sweden
Corresponding author: Solbritt Rantapää-Dahlqvist, solbritt.rantapaa.dahlqvist@medicin.umu.se
Received: 30 Jan 2007 Revisions requested: 19 Mar 2007 Revisions received: 10 May 2007 Accepted: 6 Jun 2007 Published: 6 Jun 2007
Arthritis Research Therapy 2007, 9:R56 (doi:10.1186/ar2214)
This article is online at: /content/9/3/R56
© 2007 Kokkonen et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0),
which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The PTPN22 1858C/T polymorphism has been associated with specific primers. Anti-CCP2 antibodies were determined using
several autoimmune diseases including rheumatoid arthritis enzyme-linked immunoassays. Disease activity (that is, the
(RA). We have shown that carriage of the T variant (CT or TT) of number of swollen and tender joints, the global visual analogue
PTPN22 in combination with anti-cyclic citrullinated
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