the recognition of n-glycans by the lectin artinm mediates cell death of a human myeloid leukemia cell line凝集素的识别n-glycans artinm介导细胞死亡的人类骨髓白血病细胞系.pdfVIP

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the recognition of n-glycans by the lectin artinm mediates cell death of a human myeloid leukemia cell line凝集素的识别n-glycans artinm介导细胞死亡的人类骨髓白血病细胞系.pdf

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the recognition of n-glycans by the lectin artinm mediates cell death of a human myeloid leukemia cell line凝集素的识别n-glycans artinm介导细胞死亡的人类骨髓白血病细胞系

The Recognition of N-Glycans by the Lectin ArtinM Mediates Cell Death of a Human Myeloid Leukemia Cell Line 1 2 2 ˜ Fernanda Caroline Carvalho , Sandro Gomes Soares , Mirela Barros Tamarozzi , Eduardo Magalhaes 3 1 Rego , Maria-Cristina Roque-Barreira * ˆ ˜ ˜ ˜ ˜ 1 Departamento de Biologia Celular e Molecular e Bioagentes Patogenicos, Faculdade de Medicina de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao ˜ ˜ ´ ´ ˜ Paulo, Brasil, 2 Invent Biotecnologia Ltda, Ribeirao Preto, Sao Paulo, Brasil, 3 Departamento de Clınica Medica, Faculdade de Medicina de Ribeirao Preto, Universidade de ˜ ˜ ˜ Sao Paulo, Ribeirao Preto, Sao Paulo, Brasil Abstract ArtinM, a D-mannose-binding lectin from Artocarpus heterophyllus (jackfruit), interacts with N-glycosylated receptors on the surface of several cells of hematopoietic origin, triggering cell migration, degranulation, and cytokine release. Because malignant transformation is often associated with altered expression of cell surface glycans, we evaluated the interaction of ArtinM with human myelocytic leukemia cells and investigated cellular responses to lectin binding. The intensity of ArtinM binding varied across 3 leukemia cell lines: NB4.K562.U937. The binding, which was directly related to ce