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the pharmacogenomics of anti-hypertensive therapy降压治疗的药物基因组学
Pharmaceuticals 2010, 3, 1779-1791; doi:10.3390/ph3061779
OPEN ACCESS
pharmaceuticals
ISSN 1424-8247
/journal/pharmaceuticals
Review
The Pharmacogenomics of Anti-Hypertensive Therapy
Sandosh Padmanabhan *, Laura Paul and Anna F. Dominczak
BHF Glasgow Cardiovascular Research Centre, 126 University Place, University of Glasgow,
Glasgow G12 8TA, UK; E-mails: 0506056P@student.gla.ac.uk (L.P.);
a.dominiczak@clinmed.gla.ac.uk (A.F.D)
* Author to whom correspondence should be addressed; E-mail: s.padmanabhan@clinmed.gla.ac.uk
(S.P.); Tel.: +44-141-330-8428; Fax: +44-141-330-6997
Received: 2 March 2010; in revised form: 20 May 2010 / Accepted: 26 May 2010 /
Published: 1 June 2010
Abstract: Hypertension is a major public health problem, but measures to reduce blood
pressure and thus cardiovascular risk are complicated by the high prevalence of treatment
resistance, despite the availability of multiple drugs. Drug side-effects contribute
considerably to suboptimal blood pressure control. Clinicians must often rely on empirical
methods to match patients with effective drug treatment. Hypertension pharmacogenomics
seeks to find genetic predictors of response to drugs that lower blood pressure and to
translate this knowledge into clinical practice. In this review we summarise the current
status of hypertension pharmacogenetics from monogenic hypertension to essential
hypertension and discuss the issues that need to be considered in a hypertension
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